Born in Cairo, he was raised in a family of musicians. His uncle Abu Bakr Khairat, the great Egyptian composer who established the Cairo Conservatoire and enriched Arab music with great symphonic pieces. Influenced by this legacy, Omar Khairat joined the Cairo Conservatoire in 1959, studied piano with Italian Maestro Vincenzo Carro and followed correspondence courses in music theory and composition with the Trinity College in England. Omar Khairat shaped his musical identity as a professional independent composer achieving new musical visions characterized with deepness and richness. According to music experts and critics, Omar Khairat's music bridges contemporary Arab music and Western music reflecting genuine maturity.

Khairat has composed many successful works such as The Fortune-teller, The Magic Perfumes (1989), and the Arab Rhapsody (1992). He also composed music for international events like the National Feast of Oman 1993, the Inauguration Ceremony of Bibliotheca Alexandrina 1996, Carthage Festival, Tunisia, Operetta El Sheikh Zaid, Emirates 2000, Celebration of the Royal Jordan River Institution 2005, Garash Festival 2003, Three Civilizations Celebration in Spain, and Celebration of the Centennial Anniversary of the Egyptian Cinema.